Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress

Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress

Ring finger protein 146 (RNF146) is an E3 ubiquitin ligase whose activity prevents poly (ADP-ribose) polymerase 1 (PARP1)-dependent neurodegeneration in Parkinson’s disease (PD). Previously, we reported that rhododendrin is a chemical inducer that increases RNF146 expression. However, the...

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Bibliographic Details
Main Authors: Hyojung Kim, Jisoo Park, HyunHee Leem, MyoungLae Cho, Jin-Ha Yoon, Han-Joo Maeng, Yunjong Lee
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
rhododendrin
RNF146
estrogen receptor
poly (ADP-ribose)
dopaminergic neurodegeneration
Parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/20/7/1772

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