NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving

NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving

Abstract Under adverse conditions, such as sustained or chronic hyperglycemia or hyperlipidemia, ROS (reactive oxygen species) or/and ER-stress (endoplasmic reticulum stress) will be induced in pancreatic β cells. ROS or ER-stress damages β-cells even leads to apoptosis. Previously we found ROS or E...

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Bibliographic Details
Main Authors: Ze-qing Pu, Tian-fu Yu, Dong Liu, Cheng-wen Jin, Esha Sadiq, Xiaofei Qiao, Xiaojie Li, Yuxuan Chen, Jinsong Zhang, Mingzhong Tian, Siying Li, Ru-xing Zhao, Xiang-dong Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00521-0

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