Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite

• Main Authors: El-Shahawy AAG, Abdel Moaty SA, Zaki AH, Mohamed NA, GadelHak Y, Mahmoud RK, Farghali AA
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-01-01
• Series: International Journal of Nanomedicine
• Subjects: cytotoxicity; inorganic nanomaterials; prostate cancer
• Online Access: https://www.dovepress.com/prostate-cancer-cellular-uptake-of-ternary-titanate-nanotubescufe2o4zn-peer-reviewed-article-IJN

Ahmed AG El-Shahawy, 1 SA Abdel Moaty, 2 AH Zaki, 1 Nada A Mohamed, 2 Yasser GadelHak, 1 RK Mahmoud, 2 AA Farghali 1 1Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt; 2Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, EgyptCorrespondence: Ahmed AG El-Shahawy Tel [phone]Email [e-mail]: Certainly, there is a demand for stronger recognition of how nanoparticles can move through the cell membrane. Prostate cancer is one of the forcing sources of cancer-relevant deaths among men.Aim of the Work: The current research studied the power of prostate cancer cells to uptake a ternary nanocomposite TNT/CuFe 2O 4/Zn-Fe mixed metal oxides (MMO).Methodology: The nanocomposite was synthesized by a chemical method and characterized by a High-resolution transmission electron microscope, Field emission scanning electron microscope, X-ray diffraction, Fourier transmission infra-red, X-ray photoelectron spectroscopy, dynamic light scattering. Besides, it was implemented as an inorganic anticancer agent versus Prostate cancer PC-3 cells.Results: The results revealed cellular uptake validity, cell viability reduction, ultra-structures alterations, morphological changes and membrane damage of PC-3 cells.Conclusion: The prepared ternary nanocomposite was highly uptake by PC-3 cells and possessed cytotoxicity that was dose and time-dependent. To conclude, the study offered the potential of the investigated ternary nanocomposite as a promising prostate anticancer agent.Keywords: cytotoxicity, inorganic nanomaterials, prostate cancer