HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A

HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A

Two mammalian hCYP26A expression systems have been used to analyze the metabolic products of CYP26A. Through the use of extensive HPLC, UV spectroscopy, and liquid chromatography/tandem mass spectrometry (LC-MS/MS) methodology, we have conclusively demonstrated that the complex mixture of products c...

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Bibliographic Details
Main Authors: James V. Chithalen, Luong Luu, Martin Petkovich, Glenville Jones
Format: Article
Language:English
Published: Elsevier 2002-07-01
Series:Journal of Lipid Research
Subjects:
vitamin A metabolism
retinoids
cytochrome P450
RAI-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520314760

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