Effect and mechanism analysis of continuous blood purification on acute respiratory distress syndrome

• Main Authors: Xiao-Hong Xu, Jia-Bin Chen, Yin-Wen Xia
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-01-01
• Series: Journal of Hainan Medical University
• Subjects: Continuous blood purification; Acute respiratory distress syndrome; Interleukin; ERK1/2 signal pathway; Clinical indictors
• Online Access: http://www.hnykdxxb.com/PDF/201601/44-47.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To analyze the effect and mechanism of continuous blood purification (CBP) on acute respiratory distress syndrome (ARDS) and provide reference for clinical treatment. Methods: 80 cases of patients with ARDS in our hospital were analyzed, the clinical indicators and hemodynamic parameters before and after CBP were compared, and ELISA was used to detect expression change of serum interleukin family and ERK signaling pathway protein. 80 cases of healthy subjects during the same period were taken as control group. Results: Compared with before treatment, heart rate, pulmonary artery pressure and pulmonary artery wedge pressure were effectively normalized after CBP, hemodynamic parameters were effectively improved, and compared with control group, there were significant statistical differences (P<0.05); meanwhile, after CBP, interleukins IL2, IL6 and IL10 as well as TGFβ levels significantly decreased, MEK signaling pathway protein Ras, MEK and ERK1/2 expression significantly decreased, and compared with before treatment, there were significant statistical differences (P<0.01, P<0.05). Conclusions: Continuous blood purification may play the role of treating acute respiratory distress syndrome through reducing levels of interleukins and TGFβ as well as inhibiting MEK signaling pathway