Discovery of Spatial Peptide Signatures for Neuroblastoma Risk Assessment by MALDI Mass Spectrometry Imaging

Discovery of Spatial Peptide Signatures for Neuroblastoma Risk Assessment by MALDI Mass Spectrometry Imaging

Risk classification plays a crucial role in clinical management and therapy decisions in children with neuroblastoma. Risk assessment is currently based on patient criteria and molecular factors in single tumor biopsies at diagnosis. Growing evidence of extensive neuroblastoma intratumor heterogenei...

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Bibliographic Details
Main Authors: Zhiyang Wu, Patrick Hundsdoerfer, Johannes H. Schulte, Kathy Astrahantseff, Senguel Boral, Karin Schmelz, Angelika Eggert, Oliver Klein
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
neuroblastoma
risk assessment
intratumor heterogeneity
peptide signatures
MALDI-MSI
Online Access:https://www.mdpi.com/2072-6694/13/13/3184

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