High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange
Peptide-MHC (pMHC) tetramers are important tools for probing T cell repertoire and adaptive immune responses. Here the authors use a molecular chaperone, TAPBPR, to develop a high-throughput, multiplexible platform for pMHC tetramer generation to facilitate simultaneous assessments of T cell reperto...
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Bibliographic Details
| Main Authors: |
Sarah A. Overall,
Jugmohit S. Toor,
Stephanie Hao,
Mark Yarmarkovich,
Sara M. O’Rourke,
Giora I. Morozov,
Son Nguyen,
Alberto Sada Japp,
Nicolas Gonzalez,
Danai Moschidi,
Michael R. Betts,
John M. Maris,
Peter Smibert,
Nikolaos G. Sgourakis |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-15710-1
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