Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014

• Main Authors: Guang-yao Liu, Yan Jin, Qiao Zhang, Rui Li
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-01-01
• Series: Neural Regeneration Research
• Subjects: microtubule; axon; kinesin-5; Eg5; regeneration; monastrol; molecular motor protein; aging; neurodegenerative disorders; telomere shortening; MSCs; cellular therapy; traumatic brain injury; spinal cord injuries; dual diagnosis; diagnosis; complications; rehabilitation; post-concussion syndrome; brain concussion; blood brain barrier; phage display; peptide library; nanocarrier; targeting; Schwann cells; neurite outgrowth; neuromuscular junction (NMJ); multiple sclerosis; TGF-β/BMP-7/Smad signaling; myogenic differentiation; Trf3; tumor suppression; nerve regeneration; bone marrow mesenchymal stem cells; cerebral ischemia; tail vein injection; middle cerebral artery occlusion; cell therapy; neuroprotection; brain injury; neuroimaging; ferumoxytol; superparamagnetic iron oxide particles; human adipose-derived stem cells; intracerebral injection; magnetic resonance imaging; enhanced susceptibility-weighted angiography image; modified neurological severity scores; rats; Prussian blue staining; neural regeneration; non-invasive brain stimulation; transcranial magnetic stimulation; neurotrophic factor; brain-derived neurotrophic factor; neuroplasticity; hippocampus; cognitive function; curcumin; neurons; HIV-1 gp120 V3 loop; plasticity; HIV-associated neurocognitive disorders; output/input curve; long-term potentiation; excitatory postsynaptic potential; paired-pulse facilitation; Ca 2+; synaptosome; NSFC grants; hydrogen sulfide; cerebral ischemia/reperfusion injury; P2X 7 receptor; 2; 3; 5-triphenyl-2H-tetrazolium chloride staining; animal model; protection; sodium hydrosulfide; immunofluorescence; NSFC grant; γ-aminobutyric acid; glial fibrillary acidic protein; glutamic acid decarboxylase; neurotoxicity; weaning; organ index; cerebrum; cortex; glutamate; p53 tumor suppressor gene family; cerebral ischemia/reperfusion; pyramidal neurons; CA1 region; delayed neuronal death; immunohistochemistry; western blotting; spinal cord injury; rapamycin; Wnt/β-catenin signaling pathway; apoptosis; caspase-3; loss of neurons; hydrogen-rich saline; reactive oxygen species; physiological saline; oxidative stress; Basso; Beattie and Bresnahan score; malondialdehyde; superoxide dismutase; calcitonin gene-related peptide; peripheral nerve injury; rabbits; sciatic nerve injury; autologous nerve repair; polylactic glycolic acid conduit; extracellular matrix gel; grafting; stress relaxation; creep; viscoelasticity; histomorphology; electrophysiology; pain sense model; dorsal root ganglion; primary sensory neuron; glycosylated membrane protein; sialic acid; cell electrophoresis; electrophoresis velocity; heat-hyperalgesia behavior; hyperalgesia; neuraminidase; N-propionylmannosamine; glycoengineering; sciatic nerve; peripheral nerve; branching; arborisation; Thy1-YFP mouse; stem cells; optic nerve; optic neuropathy; ophthalmology; bone marrow-derived stem cells; blindness; visual loss; gustation; cytokeratin; tongue epithelium; taste bud; trigeminal nerve disorder; nerve repair; neural transplantation; nerve transfer; tissue engineering; genetic engineering; bibliometrics; Web of Science
• Online Access: http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=996;epage=1002;aulast=Liu

Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment. Various new intervention methods have been developed, but with varying effectiveness. In the present study, we selected 911 papers on different repair methods for peripheral nerve injury from the Web of Science and indexed in the Science Citation Index from 2010 to 2014. We quantitatively examine new repair methods and strategies using bibliometrics, and we discuss the present state of knowledge and the problems and prospects of various repair methods, including nerve transfer, neural transplantation, tissue engineering and genetic engineering. Our findings should help in the study and development of repair methods for peripheral nerve injury.