Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study
The beneficial physiological effects of traditional Thai massage (TTM) have been previously documented. However, its effect on immune status, particularly in the elderly, has not been explored. This study aimed to investigate the effects of multiple rounds of TTM on senescent CD4+ T cell subsets in...
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doaj-9757a8ef1cce4ae3ac1d72a55b6cc8e62021-03-20T00:06:51ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-03-01183210321010.3390/ijerph18063210Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover StudyKanda Sornkayasit0Amonrat Jumnainsong1Wisitsak Phoksawat2Wichai Eungpinichpong3Chanvit Leelayuwat4Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, ThailandThe Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandThe Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandSchool of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandThe Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandThe beneficial physiological effects of traditional Thai massage (TTM) have been previously documented. However, its effect on immune status, particularly in the elderly, has not been explored. This study aimed to investigate the effects of multiple rounds of TTM on senescent CD4+ T cell subsets in the elderly. The study recruited 12 volunteers (61–75 years), with senescent CD4+ T cell subsets, who received six weekly 1-h TTM sessions or rest, using a randomized controlled crossover study with a 30-day washout period. Flow cytometry analysis of surface markers and intracellular cytokine staining was performed. TTM could attenuate the senescent CD4+ T cell subsets, especially in CD4+28<sup>null</sup> NKG2D+ T cells (<i>n </i>= 12; <i>p</i> < 0.001). The participants were allocated into two groups (low < 2.75% or high ≥ 2.75%) depending on the number of CD4+28<sup>null</sup> NKG2D+ T cells. After receiving TTM over 6 sessions, the cell population of the high group had significantly decreased (<i>p </i>< 0.001), but the low group had no significant changes. In conclusion, multiple rounds of TTM may promote immunity through the attenuation of aberrant CD4+ T subsets. TTM may be provided as a complementary therapy to improve the immune system in elderly populations.https://www.mdpi.com/1660-4601/18/6/3210traditional Thai massage (TTM)the elderlyCD4+ T subsetsthe natural killer group 2member D (NKG2D)interleukin-17 (IL-17) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kanda Sornkayasit Amonrat Jumnainsong Wisitsak Phoksawat Wichai Eungpinichpong Chanvit Leelayuwat |
spellingShingle |
Kanda Sornkayasit Amonrat Jumnainsong Wisitsak Phoksawat Wichai Eungpinichpong Chanvit Leelayuwat Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study International Journal of Environmental Research and Public Health traditional Thai massage (TTM) the elderly CD4+ T subsets the natural killer group 2 member D (NKG2D) interleukin-17 (IL-17) |
author_facet |
Kanda Sornkayasit Amonrat Jumnainsong Wisitsak Phoksawat Wichai Eungpinichpong Chanvit Leelayuwat |
author_sort |
Kanda Sornkayasit |
title |
Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study |
title_short |
Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study |
title_full |
Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study |
title_fullStr |
Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study |
title_full_unstemmed |
Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study |
title_sort |
traditional thai massage promoted immunity in the elderly via attenuation of senescent cd4+ t cell subsets: a randomized crossover study |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2021-03-01 |
description |
The beneficial physiological effects of traditional Thai massage (TTM) have been previously documented. However, its effect on immune status, particularly in the elderly, has not been explored. This study aimed to investigate the effects of multiple rounds of TTM on senescent CD4+ T cell subsets in the elderly. The study recruited 12 volunteers (61–75 years), with senescent CD4+ T cell subsets, who received six weekly 1-h TTM sessions or rest, using a randomized controlled crossover study with a 30-day washout period. Flow cytometry analysis of surface markers and intracellular cytokine staining was performed. TTM could attenuate the senescent CD4+ T cell subsets, especially in CD4+28<sup>null</sup> NKG2D+ T cells (<i>n </i>= 12; <i>p</i> < 0.001). The participants were allocated into two groups (low < 2.75% or high ≥ 2.75%) depending on the number of CD4+28<sup>null</sup> NKG2D+ T cells. After receiving TTM over 6 sessions, the cell population of the high group had significantly decreased (<i>p </i>< 0.001), but the low group had no significant changes. In conclusion, multiple rounds of TTM may promote immunity through the attenuation of aberrant CD4+ T subsets. TTM may be provided as a complementary therapy to improve the immune system in elderly populations. |
topic |
traditional Thai massage (TTM) the elderly CD4+ T subsets the natural killer group 2 member D (NKG2D) interleukin-17 (IL-17) |
url |
https://www.mdpi.com/1660-4601/18/6/3210 |
work_keys_str_mv |
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