Thrombin Preconditioning Enhances Therapeutic Efficacy of Human Wharton’s Jelly–Derived Mesenchymal Stem Cells in Severe Neonatal Hypoxic Ischemic Encephalopathy

Thrombin Preconditioning Enhances Therapeutic Efficacy of Human Wharton’s Jelly–Derived Mesenchymal Stem Cells in Severe Neonatal Hypoxic Ischemic Encephalopathy

We investigated whether thrombin preconditioning of human Wharton’s jelly−derived mesenchymal stem cells (MSCs) improves paracrine potency and thus the therapeutic efficacy of naïve MSCs against severe hypoxic ischemic encephalopathy (HIE). Thrombin preconditioning signi...

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Bibliographic Details
Main Authors: Young Eun Kim, Se In Sung, Yun Sil Chang, So Yoon Ahn, Dong Kyung Sung, Won Soon Park
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cell transplantation
hypoxic-ischemic encephalopathy
translational medical research
infant
newborn
diseases
Online Access:https://www.mdpi.com/1422-0067/20/10/2477

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