Structural modification of a novel inhibitor for mycobacterium enoyl-acyl carrier protein reductase assisted by In silico structure-based drug screening

Structural modification of a novel inhibitor for mycobacterium enoyl-acyl carrier protein reductase assisted by In silico structure-based drug screening

Background: Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (mtInhA) is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls, and has been targeted in the development of anti-tuberculosis (TB) drugs. In our previous in silico structure-based dr...

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Bibliographic Details
Main Authors: Junichi Taira, Toshiki Nagano, Mitsuru Kitamura, Miho Yamaguchi, Hiroshi Sakamoto, Shunsuke Aoki
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:International Journal of Mycobacteriology
Subjects:
enoyl-acyl carrier protein reductase
gold program
mycobacterium smegmatis
mycobacterium tuberculosis
structure-based drug screening
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=1;spage=12;epage=17;aulast=Taira

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=1;spage=12;epage=17;aulast=Taira

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