The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer
Infectious complications remain one of the most significant problem associated with anticancer therapy in oncological patients. Cytotoxic, radiation and antibacterial therapy induce dysbiosis and gastrointestinal mucosal barrier injury. These changes lead to the mucositis, thereby increasing the ris...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2021-06-01
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| Series: | Onkogematologiâ |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/478 |
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doaj-97419ee05a00491b916affbedf9426a62021-07-29T09:03:07ZrusABV-pressOnkogematologiâ1818-83462021-06-01162869310.17650/1818-8346-2021-16-2-86-93393The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancerD. A. Morgacheva0Yu. V. Dinikina1Yu. K. Toshina2M. B. Belogurova3V.A. Almazov National Medical Research Centre, Ministry of Health of RussiaV.A. Almazov National Medical Research Centre, Ministry of Health of RussiaV.A. Almazov National Medical Research Centre, Ministry of Health of RussiaV.A. Almazov National Medical Research Centre, Ministry of Health of RussiaInfectious complications remain one of the most significant problem associated with anticancer therapy in oncological patients. Cytotoxic, radiation and antibacterial therapy induce dysbiosis and gastrointestinal mucosal barrier injury. These changes lead to the mucositis, thereby increasing the risk of endogenous microflora translocation with following probable development of severe infectious and inflammatory diseases. In addition, current evidence suggests that there is a relationship between gut microbiome disturbances and post-transplant graft versus host disease development. The article presents the existing paradigms of determining the role of gastrointestinal tract functional condition in cancer patients in order to optimize prevention and antimicrobial treatment approaches.https://oncohematology.abvpress.ru/ongm/article/view/478pediatric oncologychemotherapymucositisfebrile neutropeniatranslocationintestinal microbiome |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
D. A. Morgacheva Yu. V. Dinikina Yu. K. Toshina M. B. Belogurova |
| spellingShingle |
D. A. Morgacheva Yu. V. Dinikina Yu. K. Toshina M. B. Belogurova The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer Onkogematologiâ pediatric oncology chemotherapy mucositis febrile neutropenia translocation intestinal microbiome |
| author_facet |
D. A. Morgacheva Yu. V. Dinikina Yu. K. Toshina M. B. Belogurova |
| author_sort |
D. A. Morgacheva |
| title |
The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer |
| title_short |
The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer |
| title_full |
The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer |
| title_fullStr |
The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer |
| title_full_unstemmed |
The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer |
| title_sort |
microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer |
| publisher |
ABV-press |
| series |
Onkogematologiâ |
| issn |
1818-8346 |
| publishDate |
2021-06-01 |
| description |
Infectious complications remain one of the most significant problem associated with anticancer therapy in oncological patients. Cytotoxic, radiation and antibacterial therapy induce dysbiosis and gastrointestinal mucosal barrier injury. These changes lead to the mucositis, thereby increasing the risk of endogenous microflora translocation with following probable development of severe infectious and inflammatory diseases. In addition, current evidence suggests that there is a relationship between gut microbiome disturbances and post-transplant graft versus host disease development. The article presents the existing paradigms of determining the role of gastrointestinal tract functional condition in cancer patients in order to optimize prevention and antimicrobial treatment approaches. |
| topic |
pediatric oncology chemotherapy mucositis febrile neutropenia translocation intestinal microbiome |
| url |
https://oncohematology.abvpress.ru/ongm/article/view/478 |
| work_keys_str_mv |
AT damorgacheva themicrobiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer AT yuvdinikina themicrobiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer AT yuktoshina themicrobiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer AT mbbelogurova themicrobiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer AT damorgacheva microbiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer AT yuvdinikina microbiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer AT yuktoshina microbiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer AT mbbelogurova microbiomeroleinpathogenesisofinflammatoryandimmunealterationsofgastrointestinaltractinpediatricpatientswithcancer |
| _version_ |
1721249544553889792 |