Proton pump inhibitors: More indigestion than relief?

• Main Authors: P Malavade, S Hiremath
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017-01-01
• Series: Indian Journal of Nephrology
• Subjects: Acute interstitial nephritis; acute kidney injury; chronic kidney disease; hypomagnesemia; proton pump inhibitors; transplant rejection
• Online Access: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2017;volume=27;issue=4;spage=249;epage=257;aulast=Malavade
• ISSN: 0971-4065; 1998-3662

Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal (GI) disorders due to excessive acid production. While effective and safe, adverse renal effects have been increasingly described in epidemiological literature. The most well-documented adverse renal outcome is acute interstitial nephritis; however, association with overall acute kidney injury has also been recently reported. Recently, two observational studies have linked PPI use with chronic kidney disease. Finally, hypomagnesemia is another reported complication and is thought to be resulting from GI loss of magnesium. This study will critically review literature on the effect of PPIs on the kidney.