Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer and is often used as a first-choice drug worldwide. Metformin mainly activates adenosine monophosphate-activated protein kinase (AMPK) in the l...

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Bibliographic Details
Main Authors: Hideaki Kaneto, Tomohiko Kimura, Atsushi Obata, Masashi Shimoda, Kohei Kaku
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
metformin
AMPK
glucagon signaling
autophagy
GDF15
gut microbiome
Online Access:https://www.mdpi.com/1422-0067/22/5/2596

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