Toll-Like Receptors: A Key Marker for Periodontal Disease and Preterm Birth – A Contemporary Review

• Main Authors: Prathahini Parthiban, Jaideep Mahendra
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2015-09-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: low birth weight infants; periodontal infection; tlr blockade
• Online Access: https://jcdr.net/articles/PDF/6526/14143_CE[Ra1]_F(AK)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdf

The receptors of the innate immune system have evolved to recognize pathogenic bacteria in a complex manner. Out of these immune receptors, the pattern recognition receptors (PRRs) such as Toll like receptors have gained importance off late to play a key role in the activation of cascade of inflammatory cytokines in pathogenesis of preterm birth. Preterm birth has become leading cause of neonatal deaths globally. The concept of oral infection influencing the occurrence of preterm delivery has gained importance. Translocation of periodontal pathogens and inflammatory mediators play role in the pathogenesis of preterm labour. The transmembrane toll like receptors of innate immunity have been recently implicated in the association of periodontal infection and preterm labour. The TLRs are considered as a key marker and TLR blockade can be a critical method for treating women who are exposed to periodontal pathogens. This review is aimed at discussing the role of TLR in periodontal disease and its relationship with preterm birth.