Toll-Like Receptors: A Key Marker for Periodontal Disease and Preterm Birth – A Contemporary Review
The receptors of the innate immune system have evolved to recognize pathogenic bacteria in a complex manner. Out of these immune receptors, the pattern recognition receptors (PRRs) such as Toll like receptors have gained importance off late to play a key role in the activation of cascade of inflam...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6526/14143_CE[Ra1]_F(AK)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | The receptors of the innate immune system have evolved to recognize pathogenic bacteria in a complex manner. Out of these immune
receptors, the pattern recognition receptors (PRRs) such as Toll like receptors have gained importance off late to play a key role in the
activation of cascade of inflammatory cytokines in pathogenesis of preterm birth. Preterm birth has become leading cause of neonatal
deaths globally. The concept of oral infection influencing the occurrence of preterm delivery has gained importance. Translocation
of periodontal pathogens and inflammatory mediators play role in the pathogenesis of preterm labour. The transmembrane toll like
receptors of innate immunity have been recently implicated in the association of periodontal infection and preterm labour. The TLRs are
considered as a key marker and TLR blockade can be a critical method for treating women who are exposed to periodontal pathogens.
This review is aimed at discussing the role of TLR in periodontal disease and its relationship with preterm birth. |
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| ISSN: | 2249-782X 0973-709X |