Acute Psychosis after Recent Isoniazid Initiation

Isoniazid as part of Directly Observed Treatment-Short course (DOTS) regimen is universally used. Although, associated psychosis in certain cases is documented earlier, type of symptoms and onset of symptoms remains highly variable. We describe a case of 54-yearold female on anti-tubercular therapy...

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Bibliographic Details
Main Authors: Sidharth Arya, Gagandeep Sukhija, Harpreet Singh
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2015-06-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/6130/12450_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdf
Description
Summary:Isoniazid as part of Directly Observed Treatment-Short course (DOTS) regimen is universally used. Although, associated psychosis in certain cases is documented earlier, type of symptoms and onset of symptoms remains highly variable. We describe a case of 54-yearold female on anti-tubercular therapy with onset of psychosis within three days of Isoniazid initiation characterised by agitation, loosening of association, echolalia with spontaneous remission after drug stoppage. This case highlights the importance of remaining vigilant and considering isoniazid as possible causative agent for psychosis even within days of its intiation and avoiding delay in management.
ISSN:2249-782X
0973-709X