Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site
Abstract Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS2–ICG hybrid with indoc...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-04-01
|
| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s40820-018-0202-8 |
| id |
doaj-97294eea76ca451693a0110356976552 |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song |
| spellingShingle |
Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site Nano-Micro Letters MoS2–ICG hybrid Orthotopic brain glioma Photoacoustic imaging Molecular imaging |
| author_facet |
Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song |
| author_sort |
Chengbo Liu |
| title |
Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site |
| title_short |
Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site |
| title_full |
Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site |
| title_fullStr |
Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site |
| title_full_unstemmed |
Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site |
| title_sort |
highly sensitive mos2–indocyanine green hybrid for photoacoustic imaging of orthotopic brain glioma at deep site |
| publisher |
SpringerOpen |
| series |
Nano-Micro Letters |
| issn |
2311-6706 2150-5551 |
| publishDate |
2018-04-01 |
| description |
Abstract Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS2–ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine. |
| topic |
MoS2–ICG hybrid Orthotopic brain glioma Photoacoustic imaging Molecular imaging |
| url |
http://link.springer.com/article/10.1007/s40820-018-0202-8 |
| work_keys_str_mv |
AT chengboliu highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT jingqinchen highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT yingzhu highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT xiaojinggong highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT rongqinzheng highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT ningbochen highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT dongchen highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT huixiangyan highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT pengzhang highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT hairongzheng highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT zonghaisheng highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite AT liangsong highlysensitivemos2indocyaninegreenhybridforphotoacousticimagingoforthotopicbraingliomaatdeepsite |
| _version_ |
1716825090947022848 |
| spelling |
doaj-97294eea76ca451693a01103569765522020-11-24T20:41:26ZengSpringerOpenNano-Micro Letters2311-67062150-55512018-04-0110311210.1007/s40820-018-0202-8Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep SiteChengbo Liu0Jingqin Chen1Ying Zhu2Xiaojing Gong3Rongqin Zheng4Ningbo Chen5Dong Chen6Huixiang Yan7Peng Zhang8Hairong Zheng9Zonghai Sheng10Liang Song11Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesResearch Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesResearch Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesResearch Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesDepartment of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-Sen UniversityResearch Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesResearch Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesResearch Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesTranslational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesResearch Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesAbstract Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS2–ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.http://link.springer.com/article/10.1007/s40820-018-0202-8MoS2–ICG hybridOrthotopic brain gliomaPhotoacoustic imagingMolecular imaging |