Recent trends from the results of clinical trials on gastric cancer surgery

• Main Authors: Takashi Kiyokawa, Takeo Fukagawa
• Format: Article
• Language: English
• Published: Wiley 2019-03-01
• Series: Cancer Communications
• Subjects: Gastric cancer; Japanese Gastric Cancer Association; Randomized clinical trials; Para-aortic lymph nodes; D2 lymphadenectomy; D3 lymphadenectomy
• Online Access: http://link.springer.com/article/10.1186/s40880-019-0360-1

Abstract The Japan Clinical Oncology Group has recently conducted large scale clinical trials with findings that have revealed pivotal strategies for the treatment of resectable gastric cancer surgery. These findings include the fact that D3 lymphadenectomy does not improve survival rates when compared to D2 lymphadenectomy, and it is not recommended for resectable gastric cancer. Also, a transhiatal approach is recommended, instead of the left thoraco-abdominal approach, for the treatment of adenocarcinoma of the esophago-gastric junction or gastric cardia which has invaded ≤ 3 cm of the esophagus. Gastrectomy with splenectomy and bursectomy had been recommended as a part of the D2 lymphadenectomy. However, the results of the recent clinical trials revealed that splenectomy should be avoided in total gastrectomy with D2 lymphadenectomy for proximal gastric cancer and that bursectomy should be avoided in gastrectomy with D2 lymphadenectomy for resectable gastric cancer. Both splenectomy and bursectomy were found to be unable to improve survival, but instead increased operative morbidity. These trials revealed that the above-mentioned invasive and aggressive procedures did not provide sufficient survival benefits and that gastric cancer surgery may be trending from an “invasive to less invasive” and “aggressive to more conservative” approach.