Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

Dopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the willingness to work by reducing inhibitory transmiss...

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Main Authors:	Eduardo F. Gallo, Jozsef Meszaros, Jeremy D. Sherman, Muhammad O. Chohan, Eric Teboul, Claire S. Choi, Holly Moore, Jonathan A. Javitch, Christoph Kellendonk
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03272-2

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spelling	doaj-9716d06b79b041318d69d2b9867976d12021-05-11T10:30:39ZengNature Publishing GroupNature Communications2041-17232018-03-019111310.1038/s41467-018-03272-2Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidumEduardo F. Gallo0Jozsef Meszaros1Jeremy D. Sherman2Muhammad O. Chohan3Eric Teboul4Claire S. Choi5Holly Moore6Jonathan A. Javitch7Christoph Kellendonk8Department of Psychiatry, College of Physicians and Surgeons, Columbia UniversityDivision of Molecular Therapeutics, New York State Psychiatric InstituteDepartment of Psychiatry, College of Physicians and Surgeons, Columbia UniversityDivision of Integrative Neuroscience, New York State Psychiatric InstituteDepartment of Psychiatry, College of Physicians and Surgeons, Columbia UniversityDepartment of Psychiatry, College of Physicians and Surgeons, Columbia UniversityDepartment of Psychiatry, College of Physicians and Surgeons, Columbia UniversityDepartment of Psychiatry, College of Physicians and Surgeons, Columbia UniversityDepartment of Psychiatry, College of Physicians and Surgeons, Columbia UniversityDopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the willingness to work by reducing inhibitory transmission to ventral pallidal neurons.https://doi.org/10.1038/s41467-018-03272-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Eduardo F. Gallo Jozsef Meszaros Jeremy D. Sherman Muhammad O. Chohan Eric Teboul Claire S. Choi Holly Moore Jonathan A. Javitch Christoph Kellendonk
spellingShingle	Eduardo F. Gallo Jozsef Meszaros Jeremy D. Sherman Muhammad O. Chohan Eric Teboul Claire S. Choi Holly Moore Jonathan A. Javitch Christoph Kellendonk Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum Nature Communications
author_facet	Eduardo F. Gallo Jozsef Meszaros Jeremy D. Sherman Muhammad O. Chohan Eric Teboul Claire S. Choi Holly Moore Jonathan A. Javitch Christoph Kellendonk
author_sort	Eduardo F. Gallo
title	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_short	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_full	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_fullStr	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_full_unstemmed	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_sort	accumbens dopamine d2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Dopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the willingness to work by reducing inhibitory transmission to ventral pallidal neurons.
url	https://doi.org/10.1038/s41467-018-03272-2
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Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

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