Reduced Fitness Costs of mcr-1.2 Compared to Mutated pmrB in Isogenic Colistin-Resistant KPC-3-Producing Klebsiella pneumoniae

Reduced Fitness Costs of mcr-1.2 Compared to Mutated pmrB in Isogenic Colistin-Resistant KPC-3-Producing Klebsiella pneumoniae

Our study shows a successful prolonged human colonization by a colistin-resistant Klebsiella pneumoniae isolate harboring mcr-1.2. An intense antibiotic therapy contributed to the maintenance of this microorganism through the acquisition of new resistance genes. The isolates carrying mcr-1.2 showed...

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Bibliographic Details
Main Authors: Cesira Giordano, Adrian Klak, Simona Barnini, Monika A. Chlebowicz, Mariacristina Menconi, John W. Rossen, Alexander W. Friedrich, Erik Bathoorn
Format: Article
Language:English
Published: American Society for Microbiology 2019-11-01
Series:mSphere
Subjects:
colistin
fitness cost
mcr-1.2
molecular epidemiology
Online Access:https://doi.org/10.1128/mSphere.00551-19

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