Fluctuation of Serum Leptin Through Menstrual Cycle in Young Fertile Women in Mosul City

• Main Authors: Rajaa A. yonis, Fadhila S. Al-Doski
• Format: Article
• Language: English
• Published: University of Mosul 2020-01-01
• Series: Annals of the College of Medicine Mosul
• Subjects: leptin; fertile women; menstrual cycle
• Online Access: https://mmed.mosuljournals.com/article_164154_3d297b65684229178e5d690a1a204c9d.pdf

<strong><em>Background:</em></strong>  Leptin  is a hormone secreted by adipocytes , it is aprotein  encoded by the ob gene.  Mutations in the ob gene in animals  cause obesity , leptin affects  nutritional homeostasis  and  reproductive function. <strong><em>Objectives :</em></strong> a  followup  study  was done  to  investigate serum leptin  levels in 30  fertile healthy normal weight  women with regular menstrual  cycle aged (8-45) years   in folicular and luteal phase of menstrual cycle. <strong><em>Methods:</em></strong> Fasting  blood samples were obtained from normal weight fertile women(BMI 19.5-24.9 Kg/m²) to measurement   serum  concentrations  of  leptin, which  measured  by  using( ELISA)  in follicular phase (2^ndday of menstriual cycle )  then ask the women to come back  and  give another blood sample in 21^st- 23^nd day of the cycle to measure serum progesterone and leptin in luteal phase of the menstrual cycle. <strong><em>Results:</em></strong> The mean  age ± SD  of the normal fertile women  was (29.1± 8.4) years, the mean weight  value ±SD  was (53±5)kg  and  the mean height   value±SD was(158 ± 6.2) cm and the mean BMI±SD  was (21.2± 1.3).     Leptin was higher in luteal phase than follicular phase in normal weight  fertile women ,this was statistically significant (p≤ 0.000), the mean   ± SD of progesterone hormone  was (7.8 ± 3.2 ) in day 21-23 of the cycle this was the indicator  for ovulation and starting of luteal phase. <strong><em>Conclusion:</em></strong> A great variation in serum leptin levels throughout the menstrual cycles with lower  levels in the follicular rather than luteal phase in normal weight fertile women is found.