A blood RNA transcript signature for TB exposure in household contacts

A blood RNA transcript signature for TB exposure in household contacts

Abstract Background Current tools for diagnosing latent TB infection (LTBI) detect immunological memory of past exposure but are unable to determine whether exposure is recent. We sought to identify a whole-blood transcriptome signature of recent TB exposure. Methods We studied household contacts of...

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Bibliographic Details
Main Authors: Philip Kam Weng Kwan, Balamurugan Periaswamy, Paola Florez De Sessions, Wenwei Lin, James S. Molton, Claire M. Naftalin, Ahmad Nazri Mohamed Naim, Martin L. Hibberd, Nicholas I. Paton
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Infectious Diseases
Subjects:
Tuberculosis; gene expression
Biomarkers
TB exposure
TB infection; RNA sequencing
Whole blood
Online Access:http://link.springer.com/article/10.1186/s12879-020-05116-1

Internet

http://link.springer.com/article/10.1186/s12879-020-05116-1

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