Epigenetic Modulation of TLR4 Expression by Sulforaphane Increases Anti-Inflammatory Capacity in Porcine Monocyte-Derived Dendritic Cells

Epigenetic Modulation of TLR4 Expression by Sulforaphane Increases Anti-Inflammatory Capacity in Porcine Monocyte-Derived Dendritic Cells

Inflammation is regulated by epigenetic modifications, including DNA methylation and histone acetylation. Sulforaphane (SFN), a histone deacetylase (HDAC) inhibitor, is also a potent immunomodulatory agent, but its anti-inflammatory functions through epigenetic modifications remain unclear. Therefor...

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Bibliographic Details
Main Authors: Xueqi Qu, Christiane Neuhoff, Mehmet Ulas Cinar, Maren Pröll, Ernst Tholen, Dawit Tesfaye, Michael Hölker, Karl Schellander, Muhammad Jasim Uddin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biology
Subjects:
epigenetic
NF-κB
pig
anti-inflammatory response
HDAC inhibitors
Online Access:https://www.mdpi.com/2079-7737/10/6/490

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