Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diab...
Main Authors: | Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, Koichi Sasaki, Michael J. V. White, Priscilla S. Briquez, Jeffrey A. Hubbell |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04525-w |
Similar Items
-
Fibronectin binding modulates CXCL11 activity and facilitates wound healing.
by: Federico Tortelli, et al.
Published: (2013-01-01) -
Would the conformation of heparin-binding peptide play a possible role in heparin binding
by: Wu Cheng-Wei, et al.
Published: (2000) -
Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis
by: Kiyomitsu Katsumata, et al.
Published: (2019-12-01) -
Structural and functional studies of a cationic heparin binding peptide
by: Fang, J.C., et al.
Published: (1998) -
Heparin binding to fibronectin
by: Sachchidanand
Published: (2001)