The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.

Bibliographic Details
Main Authors:	Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13517

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spelling	doaj-96fad901a4ef46c28beb417658674b862021-05-11T11:16:53ZengNature Publishing GroupNature Communications2041-17232016-11-017111410.1038/ncomms13517The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularizationFeng Zhang0Claudia Prahst1Thomas Mathivet2Laurence Pibouin-Fragner3Jiasheng Zhang4Gael Genet5Raymond Tong6Alexandre Dubrac7Anne Eichmann8Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of MedicineINSERM U970, Paris Center for Cardiovascular Research (PARCC)INSERM U970, Paris Center for Cardiovascular Research (PARCC)Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of MedicineMolecular Oncology Division, Genentech Inc.Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of MedicineRobo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.https://doi.org/10.1038/ncomms13517
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Feng Zhang Claudia Prahst Thomas Mathivet Laurence Pibouin-Fragner Jiasheng Zhang Gael Genet Raymond Tong Alexandre Dubrac Anne Eichmann
spellingShingle	Feng Zhang Claudia Prahst Thomas Mathivet Laurence Pibouin-Fragner Jiasheng Zhang Gael Genet Raymond Tong Alexandre Dubrac Anne Eichmann The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization Nature Communications
author_facet	Feng Zhang Claudia Prahst Thomas Mathivet Laurence Pibouin-Fragner Jiasheng Zhang Gael Genet Raymond Tong Alexandre Dubrac Anne Eichmann
author_sort	Feng Zhang
title	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_short	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_full	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_fullStr	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_full_unstemmed	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_sort	robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-11-01
description	Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.
url	https://doi.org/10.1038/ncomms13517
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The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

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