Zinc and Traumatic Brain Injury: From Chelation to Supplementation

• Main Author: Cathy W. Levenson
• Format: Article
• Language: English
• Published: MDPI AG 2020-08-01
• Series: Medical Sciences
• Subjects: brain injury; trauma; zinc; excitotoxicity; neuroprotection; chelation
• Online Access: https://www.mdpi.com/2076-3271/8/3/36

With a worldwide incidence rate of almost 70 million annually, traumatic brain injury (TBI) is a frequent cause of both disability and death. Our modern understanding of the zinc-regulated neurochemical, cellular, and molecular mechanisms associated with TBI is the result of a continuum of research spanning more than three decades. This review describes the evolution of the field beginning with the initial landmark work on the toxicity of excess neuronal zinc accumulation after injury. It further shows how the field has expanded and shifted to include examination of the cellular pools of zinc after TBI, identification of the role of zinc in TBI-regulated gene expression and neurogenesis, and the use of zinc to prevent cognitive and behavioral deficits associated with brain injury.