Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.

Bibliographic Details
Main Authors: Sjors P. W. Wijnands, Wouter Engelen, René P. M. Lafleur, E. W. Meijer, Maarten Merkx
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02559-0
id doaj-96f21eff2c8d4ad2bfb01b1a20c40bed
record_format Article
spelling doaj-96f21eff2c8d4ad2bfb01b1a20c40bed2021-05-11T10:31:37ZengNature Publishing GroupNature Communications2041-17232018-01-01911910.1038/s41467-017-02559-0Controlling protein activity by dynamic recruitment on a supramolecular polymer platformSjors P. W. Wijnands0Wouter Engelen1René P. M. Lafleur2E. W. Meijer3Maarten Merkx4Institute for Complex Molecular Systems, Eindhoven University of TechnologyInstitute for Complex Molecular Systems, Eindhoven University of TechnologyInstitute for Complex Molecular Systems, Eindhoven University of TechnologyInstitute for Complex Molecular Systems, Eindhoven University of TechnologyInstitute for Complex Molecular Systems, Eindhoven University of TechnologyDNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.https://doi.org/10.1038/s41467-017-02559-0
collection DOAJ
language English
format Article
sources DOAJ
author Sjors P. W. Wijnands
Wouter Engelen
René P. M. Lafleur
E. W. Meijer
Maarten Merkx
spellingShingle Sjors P. W. Wijnands
Wouter Engelen
René P. M. Lafleur
E. W. Meijer
Maarten Merkx
Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
Nature Communications
author_facet Sjors P. W. Wijnands
Wouter Engelen
René P. M. Lafleur
E. W. Meijer
Maarten Merkx
author_sort Sjors P. W. Wijnands
title Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_short Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_full Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_fullStr Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_full_unstemmed Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_sort controlling protein activity by dynamic recruitment on a supramolecular polymer platform
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.
url https://doi.org/10.1038/s41467-017-02559-0
work_keys_str_mv AT sjorspwwijnands controllingproteinactivitybydynamicrecruitmentonasupramolecularpolymerplatform
AT wouterengelen controllingproteinactivitybydynamicrecruitmentonasupramolecularpolymerplatform
AT renepmlafleur controllingproteinactivitybydynamicrecruitmentonasupramolecularpolymerplatform
AT ewmeijer controllingproteinactivitybydynamicrecruitmentonasupramolecularpolymerplatform
AT maartenmerkx controllingproteinactivitybydynamicrecruitmentonasupramolecularpolymerplatform
_version_ 1721448072304656384

Similar Items