Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.

Bibliographic Details
Main Authors: Sjors P. W. Wijnands, Wouter Engelen, René P. M. Lafleur, E. W. Meijer, Maarten Merkx
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02559-0
Description
Summary:DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.
ISSN:2041-1723

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