Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP

The metabolism of amyloid precursor protein (APP) is central to Alzheimer's disease pathogenesis. Recent data have linked APP and presenilin to the Wnt/wingless signaling pathway. To assess affects of Wnt stimulation on APP isoform expression, we infected PC12 cells and C57MG cells with a retro...

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Main Authors: Peter J Morin, Miguel Medina, Mikhail Semenov, Anthony M.C Brown, Kenneth S Kosik
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Neurobiology of Disease
Subjects:
Wnt-1
APP isoform
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104000105
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spelling doaj-96ec0f66f9b746e193a05c3bf2e72f1e2021-03-20T04:49:22ZengElsevierNeurobiology of Disease1095-953X2004-06-011615967Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APPPeter J Morin0Miguel Medina1Mikhail Semenov2Anthony M.C Brown3Kenneth S Kosik4Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USACenter for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USACenter for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USACenter for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USACenter for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USAThe metabolism of amyloid precursor protein (APP) is central to Alzheimer's disease pathogenesis. Recent data have linked APP and presenilin to the Wnt/wingless signaling pathway. To assess affects of Wnt stimulation on APP isoform expression, we infected PC12 cells and C57MG cells with a retrovirus containing murine Wnt-1. In PC12 cells, Wnt-1 expression is associated with induction of exon 15 deletion from APP mRNA and expression of L-APP. Our data suggest that APP isoform expression is regulated, in part, by the Wnt/wingless signaling pathway.http://www.sciencedirect.com/science/article/pii/S0969996104000105Wnt-1APP isoformAlzheimer's disease
collection DOAJ
language English
format Article
sources DOAJ
author Peter J Morin
Miguel Medina
Mikhail Semenov
Anthony M.C Brown
Kenneth S Kosik
spellingShingle Peter J Morin
Miguel Medina
Mikhail Semenov
Anthony M.C Brown
Kenneth S Kosik
Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP
Neurobiology of Disease
Wnt-1
APP isoform
Alzheimer's disease
author_facet Peter J Morin
Miguel Medina
Mikhail Semenov
Anthony M.C Brown
Kenneth S Kosik
author_sort Peter J Morin
title Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP
title_short Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP
title_full Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP
title_fullStr Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP
title_full_unstemmed Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP
title_sort wnt-1 expression in pc12 cells induces exon 15 deletion and expression of l-app
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2004-06-01
description The metabolism of amyloid precursor protein (APP) is central to Alzheimer's disease pathogenesis. Recent data have linked APP and presenilin to the Wnt/wingless signaling pathway. To assess affects of Wnt stimulation on APP isoform expression, we infected PC12 cells and C57MG cells with a retrovirus containing murine Wnt-1. In PC12 cells, Wnt-1 expression is associated with induction of exon 15 deletion from APP mRNA and expression of L-APP. Our data suggest that APP isoform expression is regulated, in part, by the Wnt/wingless signaling pathway.
topic Wnt-1
APP isoform
Alzheimer's disease
url http://www.sciencedirect.com/science/article/pii/S0969996104000105
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AT miguelmedina wnt1expressioninpc12cellsinducesexon15deletionandexpressionoflapp
AT mikhailsemenov wnt1expressioninpc12cellsinducesexon15deletionandexpressionoflapp
AT anthonymcbrown wnt1expressioninpc12cellsinducesexon15deletionandexpressionoflapp
AT kennethskosik wnt1expressioninpc12cellsinducesexon15deletionandexpressionoflapp
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