Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed apprecia...

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Main Authors:	Leticia Moreira, Basil Bakir, Priya Chatterji, Zahra Dantes, Maximilian Reichert, Anil K. Rustgi
Format:	Article
Language:	English
Published:	Elsevier 2018-01-01
Series:	Cellular and Molecular Gastroenterology and Hepatology
Subjects:	3D Organoids Pancreas Adenocarcinoma Personalized Medicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X17301832

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spelling	doaj-96e98ac2393948aaac4097c1d00f97332020-11-24T22:11:47ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2018-01-015328929810.1016/j.jcmgh.2017.12.004Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic CancerLeticia Moreira0Basil Bakir1Priya Chatterji2Zahra Dantes3Maximilian Reichert4Anil K. Rustgi5Division of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PennsylvaniaDivision of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PennsylvaniaDivision of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PennsylvaniaII. Medizinische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische Universität München, Munich, GermanyII. Medizinische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische Universität München, Munich, GermanyDivision of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PennsylvaniaPancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.http://www.sciencedirect.com/science/article/pii/S2352345X173018323D OrganoidsPancreasAdenocarcinomaPersonalized Medicine
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Leticia Moreira Basil Bakir Priya Chatterji Zahra Dantes Maximilian Reichert Anil K. Rustgi
spellingShingle	Leticia Moreira Basil Bakir Priya Chatterji Zahra Dantes Maximilian Reichert Anil K. Rustgi Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer Cellular and Molecular Gastroenterology and Hepatology 3D Organoids Pancreas Adenocarcinoma Personalized Medicine
author_facet	Leticia Moreira Basil Bakir Priya Chatterji Zahra Dantes Maximilian Reichert Anil K. Rustgi
author_sort	Leticia Moreira
title	Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_short	Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_full	Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_fullStr	Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_full_unstemmed	Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_sort	pancreas 3d organoids: current and future aspects as a research platform for personalized medicine in pancreatic cancer
publisher	Elsevier
series	Cellular and Molecular Gastroenterology and Hepatology
issn	2352-345X
publishDate	2018-01-01
description	Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.
topic	3D Organoids Pancreas Adenocarcinoma Personalized Medicine
url	http://www.sciencedirect.com/science/article/pii/S2352345X17301832
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Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

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