The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright

The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright

MicroRNAs represent a class of non-coding RNA molecules that negatively regulate gene expression either by repressing translation or by inducing degradation of messenger RNA. Studies have shown that, as regulators of gene expression, microRNAs are widely involved in various human diseases, including...

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Main Authors: Kangkang Yu, Guangfeng Shi, Ning Li
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Annals of Hepatology
Subjects:
Small RNA
Chronic Hepatitis B
Hepatocellular carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119311652
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spelling doaj-96e1896d08564f6b969017895fc78c8e2021-06-09T05:53:43ZengElsevierAnnals of Hepatology1665-26812015-07-01144450456The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to BrightKangkang Yu0Guangfeng Shi1Ning Li2Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, ChinaCorrespondence and reprint request:; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, ChinaMicroRNAs represent a class of non-coding RNA molecules that negatively regulate gene expression either by repressing translation or by inducing degradation of messenger RNA. Studies have shown that, as regulators of gene expression, microRNAs are widely involved in various human diseases, including hepatitis B virus-related liver diseases. By modulating hepatitis B virus replication, regulating extracellular matrix formation, as well as silencing tumor suppressor genes, these small molecules are implicated in the development of chronic hepatitis, liver fibrosis/cirrhosis, and hepatocellular carcinoma caused by hepatitis B virus infection. In addition, current researches indicated a potential role of microRNA as diagnostic markers and therapeutic targets. In conclusion, microRNAs are promising tools in the diagnosis and treatment of hepatitis B virus -related liver diseases.http://www.sciencedirect.com/science/article/pii/S1665268119311652Small RNAChronic Hepatitis BHepatocellular carcinoma
collection DOAJ
language English
format Article
sources DOAJ
author Kangkang Yu
Guangfeng Shi
Ning Li
spellingShingle Kangkang Yu
Guangfeng Shi
Ning Li
The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright
Annals of Hepatology
Small RNA
Chronic Hepatitis B
Hepatocellular carcinoma
author_facet Kangkang Yu
Guangfeng Shi
Ning Li
author_sort Kangkang Yu
title The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright
title_short The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright
title_full The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright
title_fullStr The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright
title_full_unstemmed The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright
title_sort function of microrna in hepatitis b virus-related liver diseases: from dim to bright
publisher Elsevier
series Annals of Hepatology
issn 1665-2681
publishDate 2015-07-01
description MicroRNAs represent a class of non-coding RNA molecules that negatively regulate gene expression either by repressing translation or by inducing degradation of messenger RNA. Studies have shown that, as regulators of gene expression, microRNAs are widely involved in various human diseases, including hepatitis B virus-related liver diseases. By modulating hepatitis B virus replication, regulating extracellular matrix formation, as well as silencing tumor suppressor genes, these small molecules are implicated in the development of chronic hepatitis, liver fibrosis/cirrhosis, and hepatocellular carcinoma caused by hepatitis B virus infection. In addition, current researches indicated a potential role of microRNA as diagnostic markers and therapeutic targets. In conclusion, microRNAs are promising tools in the diagnosis and treatment of hepatitis B virus -related liver diseases.
topic Small RNA
Chronic Hepatitis B
Hepatocellular carcinoma
url http://www.sciencedirect.com/science/article/pii/S1665268119311652
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