Staphylococcus aureus Quorum Regulator SarA Targeted Compound, 2-[(Methylamino)methyl]phenol Inhibits Biofilm and Down-Regulates Virulence Genes

Staphylococcus aureus Quorum Regulator SarA Targeted Compound, 2-[(Methylamino)methyl]phenol Inhibits Biofilm and Down-Regulates Virulence Genes

Staphylococcus aureus is a widely acknowledged Gram-positive pathogen for forming biofilm and virulence gene expressions by quorum sensing (QS), a cell to cell communication process. The quorum regulator SarA of S. aureus up-regulates the expression of many virulence factors including biofilm format...

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Bibliographic Details
Main Authors: P. Balamurugan, V. Praveen Krishna, D. Bharath, Raajaraam Lavanya, Pothiappan Vairaprakash, S. Adline Princy
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Microbiology
Subjects:
Staphylococcus aureus
SarA
antibiotics
quorum sensing
RT-PCR
multidrug resistance
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01290/full

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