Pathological Fractures in Primary Non-Hodgkin’s Lymphoma of the Bone: A Case Series with Review of the Literature

• Main Authors: Yasir Salam Siddiqui, Abdul Qayyum Khan, MKA Sherwani
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2013-03-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: primary non-hodgkin’s lymphoma of bone; chemotherapy; pathological fractures
• Online Access: https://jcdr.net/articles/PDF/2809/23%20-%203948.pdf
• ISSN: 2249-782X; 0973-709X

Primary non-Hodgkin’s lymphoma of bone (PLB) is a rare entity. Patients generally present with localized bone pain and, less frequently, soft-tissue swelling or a palpable mass. Pathological fracture of the proximal femur and proximal humerus secondary to soft-tissue tumours is well documented in the literature; however, lymphomas presenting primarily at these sites with pathological fracture is unusual. A review of the world literature shows that the incidence of skeletal manifestation from NHL is less than 5%, and in all these cases, bony involvement was reported many years after presentation of the primary cancer. Histopathologically, PLB usually represents diffuse large B-cell lymphoma. We report our experience with two cases of Primary non-Hodgkin’s lymphoma of proximal femur and proximal humerus with pathological fracture and their management.