Advanced oxidation protein products induce G1 phase arrest in intestinal epithelial cells via a RAGE/CD36-JNK-p27kip1 mediated pathway

Intestinal epithelial cell (IEC) cycle arrest has recently been found to be involved in the pathogenesis of Crohn's disease (CD). However, the mechanism underlying the regulation of this form of cell cycle arrest, remains unclear. Here, we investigated the roles that advanced oxidation protein...

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Bibliographic Details
Main Authors: Jie Shi, Shibo Sun, Yan Liao, Jing Tang, Xiaoping Xu, Biyan Qin, Caolitao Qin, Lishan Peng, Mengshi Luo, Lan Bai, Fang Xie
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718310553