The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives

The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives

Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental conditions, characterized by a wide genetic variability that has led to hypothesize a polygenic origin. The metabolic profiles of patients with ASD suggest a possible implication of mitochondrial pathways. Although...

Full description

Bibliographic Details
Main Authors: Luigi Citrigno, Maria Muglia, Antonio Qualtieri, Patrizia Spadafora, Francesca Cavalcanti, Giovanni Pioggia, Antonio Cerasa
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
autism spectrum disorder (ASD)
mitochondrial DNA (mtDNA)
mitochondrial dysfunctions
next generation sequencing (NGS)
Online Access:https://www.mdpi.com/1422-0067/21/16/5785
Description
Summary:Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental conditions, characterized by a wide genetic variability that has led to hypothesize a polygenic origin. The metabolic profiles of patients with ASD suggest a possible implication of mitochondrial pathways. Although different physiological and biochemical studies reported deficits in mitochondrial oxidative phosphorylation in subjects with ASD, the role of mitochondrial DNA variations has remained relatively unexplored. In this review, we report and discuss very recent evidence to demonstrate the key role of mitochondrial disorders in the development of ASD.
ISSN:1661-6596
1422-0067

Similar Items