Blocking TRPA1 and TNF-α Signal Improves Bortezomib-Induced Neuropathic Pain

Blocking TRPA1 and TNF-α Signal Improves Bortezomib-Induced Neuropathic Pain

Background/Aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of multiple myeloma. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. The purpose of this study was to examine the underlying mechanisms l...

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Bibliographic Details
Main Authors: Chunrui Li, Taoran Deng, Zhen Shang, Di Wang, Yi Xiao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Chemotherapeutics
Multiple myeloma
Bortezomib
Neuropathy
TRPA1
TNF-α
Online Access:https://www.karger.com/Article/FullText/495828

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