Characteristics of Laboratory Biomarkers Associated with Hypercoagulability in Lung Cancer Patients During Perioperative Period and Its Diagnostic Value for Deep Venous Thrombosis

• Main Authors: FANG Qiang, HUANG Jianming, WANG Kangning, ZHOU Hong, HAN Yongtao
• Format: Article
• Language: zho
• Published: Magazine House of Cancer Research on Prevention and Treatment 2019-12-01
• Series: Zhongliu Fangzhi Yanjiu
• Subjects: lung cancer; perioperative period; hypercoagulability; deep venous thrombosis
• Online Access: http://html.rhhz.net/ZLFZYJ/html/8578.2019.19.0591.htm
• ISSN: 1000-8578; 1000-8578

Objective To analyze the characteristics of laboratory biomarkers associated with hypercoagulability in patients undergoing lung cancer surgery during the perioperative period and its diagnostic value for deep venous thrombosis (DVT). Methods We enrolled 143 patients treated with lung cancer surgery based on eligibility criteria. The lower extremity deep vein was examined perioperatively by compressed ultrasonic (CUS) to determine the DVT. The laboratory biomarkers associated with hypercoagulability were measured. We analyzed the area under curve (AUC) of ROC and cutoff in DVT (+) and DVT (-) groups with significant different biomarkers. Results Thirty-three patients with DVT were first diagnosed from the postoperative 3rd day (POD3) to 7th day (POD7). The fibrinogen degradation product (FDP), D-Dimer, brain natriuretic peptide and C reactive protein were significantly increased in the postoperative POD1-POD7 (P < 0.05). There were significant differences in the change levels of FDP and D-D during the perioperative period between the DVT (+) and DVT (-) groups (P < 0.05). The AUC and diagnostic cutoff values of POD1-FDP, POD3-FDP, POD3-D-D were 0.726 and 4.65μg/ml, 0.811 and 4.85 μg/ml, 0.772 and 1.55 μg/ml, respectively. The sensitivity and specificity of serial test were 46.5% and 94.9% for the combined diagnosis. Conclusion The value of increased levels of POD1-FDP, POD3-FDP and POD3-D-Dimer for DVT diagnosis is moderate. The combined diagnosis with serial test could improve the specificity of diagnosis.