Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
Objective: To investigate the regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity. Methods: A total of 118 patients with newly diagnosed type 2 diabetes complicated with obesity who were treated in the hospital...
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Editorial Board of Journal of Hainan Medical University
2017-08-01
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doaj-96ad58b3ce8e4ae68e47548f1e66764e2020-11-24T23:19:50ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-08-0123163740Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesityDong-Mei Gao0Shan-Dan Bao1 Department of General Practice, Puhuangyu Community Health Service Center of Fengtai District Beijing, Fengtai District, Beijing 100075Department of Endocrine, the First Hospital of Fangshan District Beijing, Fangshan District, Beijing 102400Objective: To investigate the regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity. Methods: A total of 118 patients with newly diagnosed type 2 diabetes complicated with obesity who were treated in the hospital between September 2014 and January 2017 were collected and divided into the control group (n=59) and observation group (n=59) by random number table. Control group received metformin therapy and the observation group received liraglutide therapy. The differences in levels of glucose metabolism indexes, lipid metabolism indexes and inflammatory factors were compared between the two groups before and after 4 months of treatment. Results: Before treatment, the differences in serum levels of glucose metabolism indexes, lipid metabolism indexes and inflammatory factors were not statistically significant between the two groups. after 4 months of treatment, serum FPG, FIN, F-CP, TC, TG, IL- 1β, IL-6, CRP and TNF-α levels of both groups of patients were lower than those before treatment while HDL-C levels were higher than those before treatment, and serum FPG, FIN, F-CP, TC, TG, IL-1β, IL-6, CRP and TNF-α levels of observation group were lower than those of control group while HDL-C level was higher than that of control group. Conclusion: Liraglutide therapy can effectively optimize the glucose lipid metabolism and reduce the microinflammatory response in patients with type 2 diabetes mellitus complicated with obesity.http://www.hnykdxxb.com/PDF/201716/10.pdfType 2 diabetes mellitusObesityLiraglutideLipid metabolismInflammatory response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong-Mei Gao Shan-Dan Bao |
spellingShingle |
Dong-Mei Gao Shan-Dan Bao Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity Journal of Hainan Medical University Type 2 diabetes mellitus Obesity Liraglutide Lipid metabolism Inflammatory response |
author_facet |
Dong-Mei Gao Shan-Dan Bao |
author_sort |
Dong-Mei Gao |
title |
Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity |
title_short |
Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity |
title_full |
Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity |
title_fullStr |
Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity |
title_full_unstemmed |
Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity |
title_sort |
regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-08-01 |
description |
Objective: To investigate the regulating effect of liraglutide therapy on metabolic disorders
in patients with newly diagnosed type 2 diabetes complicated with obesity. Methods: A
total of 118 patients with newly diagnosed type 2 diabetes complicated with obesity who
were treated in the hospital between September 2014 and January 2017 were collected and
divided into the control group (n=59) and observation group (n=59) by random number table.
Control group received metformin therapy and the observation group received liraglutide
therapy. The differences in levels of glucose metabolism indexes, lipid metabolism indexes
and inflammatory factors were compared between the two groups before and after 4 months
of treatment. Results: Before treatment, the differences in serum levels of glucose metabolism
indexes, lipid metabolism indexes and inflammatory factors were not statistically significant
between the two groups. after 4 months of treatment, serum FPG, FIN, F-CP, TC, TG, IL-
1β, IL-6, CRP and TNF-α levels of both groups of patients were lower than those before
treatment while HDL-C levels were higher than those before treatment, and serum FPG, FIN,
F-CP, TC, TG, IL-1β, IL-6, CRP and TNF-α levels of observation group were lower than
those of control group while HDL-C level was higher than that of control group. Conclusion:
Liraglutide therapy can effectively optimize the glucose lipid metabolism and reduce the
microinflammatory response in patients with type 2 diabetes mellitus complicated with obesity. |
topic |
Type 2 diabetes mellitus Obesity Liraglutide Lipid metabolism Inflammatory response |
url |
http://www.hnykdxxb.com/PDF/201716/10.pdf |
work_keys_str_mv |
AT dongmeigao regulatingeffectofliraglutidetherapyonmetabolicdisordersinpatientswithnewlydiagnosedtype2diabetescomplicatedwithobesity AT shandanbao regulatingeffectofliraglutidetherapyonmetabolicdisordersinpatientswithnewlydiagnosedtype2diabetescomplicatedwithobesity |
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