Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity

Objective: To investigate the regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity. Methods: A total of 118 patients with newly diagnosed type 2 diabetes complicated with obesity who were treated in the hospital...

Full description

Bibliographic Details
Main Authors: Dong-Mei Gao, Shan-Dan Bao
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2017-08-01
Series:Journal of Hainan Medical University
Subjects:
Online Access:http://www.hnykdxxb.com/PDF/201716/10.pdf
id doaj-96ad58b3ce8e4ae68e47548f1e66764e
record_format Article
spelling doaj-96ad58b3ce8e4ae68e47548f1e66764e2020-11-24T23:19:50ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-08-0123163740Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesityDong-Mei Gao0Shan-Dan Bao1 Department of General Practice, Puhuangyu Community Health Service Center of Fengtai District Beijing, Fengtai District, Beijing 100075Department of Endocrine, the First Hospital of Fangshan District Beijing, Fangshan District, Beijing 102400Objective: To investigate the regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity. Methods: A total of 118 patients with newly diagnosed type 2 diabetes complicated with obesity who were treated in the hospital between September 2014 and January 2017 were collected and divided into the control group (n=59) and observation group (n=59) by random number table. Control group received metformin therapy and the observation group received liraglutide therapy. The differences in levels of glucose metabolism indexes, lipid metabolism indexes and inflammatory factors were compared between the two groups before and after 4 months of treatment. Results: Before treatment, the differences in serum levels of glucose metabolism indexes, lipid metabolism indexes and inflammatory factors were not statistically significant between the two groups. after 4 months of treatment, serum FPG, FIN, F-CP, TC, TG, IL- 1β, IL-6, CRP and TNF-α levels of both groups of patients were lower than those before treatment while HDL-C levels were higher than those before treatment, and serum FPG, FIN, F-CP, TC, TG, IL-1β, IL-6, CRP and TNF-α levels of observation group were lower than those of control group while HDL-C level was higher than that of control group. Conclusion: Liraglutide therapy can effectively optimize the glucose lipid metabolism and reduce the microinflammatory response in patients with type 2 diabetes mellitus complicated with obesity.http://www.hnykdxxb.com/PDF/201716/10.pdfType 2 diabetes mellitusObesityLiraglutideLipid metabolismInflammatory response
collection DOAJ
language English
format Article
sources DOAJ
author Dong-Mei Gao
Shan-Dan Bao
spellingShingle Dong-Mei Gao
Shan-Dan Bao
Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
Journal of Hainan Medical University
Type 2 diabetes mellitus
Obesity
Liraglutide
Lipid metabolism
Inflammatory response
author_facet Dong-Mei Gao
Shan-Dan Bao
author_sort Dong-Mei Gao
title Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
title_short Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
title_full Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
title_fullStr Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
title_full_unstemmed Regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
title_sort regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity
publisher Editorial Board of Journal of Hainan Medical University
series Journal of Hainan Medical University
issn 1007-1237
1007-1237
publishDate 2017-08-01
description Objective: To investigate the regulating effect of liraglutide therapy on metabolic disorders in patients with newly diagnosed type 2 diabetes complicated with obesity. Methods: A total of 118 patients with newly diagnosed type 2 diabetes complicated with obesity who were treated in the hospital between September 2014 and January 2017 were collected and divided into the control group (n=59) and observation group (n=59) by random number table. Control group received metformin therapy and the observation group received liraglutide therapy. The differences in levels of glucose metabolism indexes, lipid metabolism indexes and inflammatory factors were compared between the two groups before and after 4 months of treatment. Results: Before treatment, the differences in serum levels of glucose metabolism indexes, lipid metabolism indexes and inflammatory factors were not statistically significant between the two groups. after 4 months of treatment, serum FPG, FIN, F-CP, TC, TG, IL- 1β, IL-6, CRP and TNF-α levels of both groups of patients were lower than those before treatment while HDL-C levels were higher than those before treatment, and serum FPG, FIN, F-CP, TC, TG, IL-1β, IL-6, CRP and TNF-α levels of observation group were lower than those of control group while HDL-C level was higher than that of control group. Conclusion: Liraglutide therapy can effectively optimize the glucose lipid metabolism and reduce the microinflammatory response in patients with type 2 diabetes mellitus complicated with obesity.
topic Type 2 diabetes mellitus
Obesity
Liraglutide
Lipid metabolism
Inflammatory response
url http://www.hnykdxxb.com/PDF/201716/10.pdf
work_keys_str_mv AT dongmeigao regulatingeffectofliraglutidetherapyonmetabolicdisordersinpatientswithnewlydiagnosedtype2diabetescomplicatedwithobesity
AT shandanbao regulatingeffectofliraglutidetherapyonmetabolicdisordersinpatientswithnewlydiagnosedtype2diabetescomplicatedwithobesity
_version_ 1725576593698455552