Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity

Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity

Amino-bis-phosphonates (N-BPs) such as zoledronate (Zol) have been used in anticancer clinical trials due to their ability to upregulate pyrophosphate accumulation promoting antitumor Vγ9Vδ2 T cells. The butyrophilin 3A (BTN3A, CD277) family, mainly the BTN3A1 isoform, has emerged as an important st...

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Bibliographic Details
Main Authors: Maria Raffaella Zocchi, Delfina Costa, Roberta Venè, Francesca Tosetti, Nicoletta Ferrari, Simona Minghelli, Roberto Benelli, Stefano Scabini, Emanuele Romairone, Silvia Catellani, Aldo Profumo, Alessandro Poggi
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:OncoImmunology
Subjects:
amino-bis-phosphonates
butyrophilin
colorectal cancer
immunostimulation
phosphate antigens
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1278099

Internet

http://dx.doi.org/10.1080/2162402X.2016.1278099

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