Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine
Synthesis and characterization of (1E)-1-(4-chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine (4) are reported. X-ray crystal structure of the title oxime 4 confirmed its assigned (E)-configuration. The compound crystallizes in the monoclinic space group P21/c with a=13.4292 (3) Å, b=8.8343...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2013-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/418601 |
| id |
doaj-969a96dec8a04401bc325e8145d0f256 |
|---|---|
| record_format |
Article |
| spelling |
doaj-969a96dec8a04401bc325e8145d0f2562020-11-24T22:42:26ZengHindawi LimitedJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/418601418601Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imineMohamed I. Attia0Hazem A. Ghabbour1Maha S. Almutairi2Soraya W. Ghoneim3Hatem A. Abdel-Aziz4Hoong-Kun Fun5Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaSynthesis and characterization of (1E)-1-(4-chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine (4) are reported. X-ray crystal structure of the title oxime 4 confirmed its assigned (E)-configuration. The compound crystallizes in the monoclinic space group P21/c with a=13.4292 (3) Å, b=8.8343 (2) Å, c=11.1797 (3) Å, α=90°, β=108.873 (2)°, γ=90°, V=1255.03 (5) Å3, and Z=4. The molecules are packed in crystal structure by weak intermolecular O–H⋯N hydrogen bonding interactions. Compound 4 is a useful intermediate for the synthesis of new imidazole-containing antifungal agents.http://dx.doi.org/10.1155/2013/418601 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mohamed I. Attia Hazem A. Ghabbour Maha S. Almutairi Soraya W. Ghoneim Hatem A. Abdel-Aziz Hoong-Kun Fun |
| spellingShingle |
Mohamed I. Attia Hazem A. Ghabbour Maha S. Almutairi Soraya W. Ghoneim Hatem A. Abdel-Aziz Hoong-Kun Fun Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine Journal of Chemistry |
| author_facet |
Mohamed I. Attia Hazem A. Ghabbour Maha S. Almutairi Soraya W. Ghoneim Hatem A. Abdel-Aziz Hoong-Kun Fun |
| author_sort |
Mohamed I. Attia |
| title |
Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine |
| title_short |
Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine |
| title_full |
Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine |
| title_fullStr |
Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine |
| title_full_unstemmed |
Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine |
| title_sort |
synthesis and x-ray crystal structure of (1e)-1-(4-chlorophenyl)-n-hydroxy-3-(1h-imidazol-1-yl)propan-1-imine |
| publisher |
Hindawi Limited |
| series |
Journal of Chemistry |
| issn |
2090-9063 2090-9071 |
| publishDate |
2013-01-01 |
| description |
Synthesis and characterization of (1E)-1-(4-chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine (4) are reported. X-ray crystal structure of the title oxime 4 confirmed its assigned (E)-configuration. The compound crystallizes in the monoclinic space group P21/c with a=13.4292 (3) Å, b=8.8343 (2) Å, c=11.1797 (3) Å, α=90°, β=108.873 (2)°, γ=90°, V=1255.03 (5) Å3, and Z=4. The molecules are packed in crystal structure by weak intermolecular O–H⋯N hydrogen bonding interactions. Compound 4 is a useful intermediate for the synthesis of new imidazole-containing antifungal agents. |
| url |
http://dx.doi.org/10.1155/2013/418601 |
| work_keys_str_mv |
AT mohamediattia synthesisandxraycrystalstructureof1e14chlorophenylnhydroxy31himidazol1ylpropan1imine AT hazemaghabbour synthesisandxraycrystalstructureof1e14chlorophenylnhydroxy31himidazol1ylpropan1imine AT mahasalmutairi synthesisandxraycrystalstructureof1e14chlorophenylnhydroxy31himidazol1ylpropan1imine AT sorayawghoneim synthesisandxraycrystalstructureof1e14chlorophenylnhydroxy31himidazol1ylpropan1imine AT hatemaabdelaziz synthesisandxraycrystalstructureof1e14chlorophenylnhydroxy31himidazol1ylpropan1imine AT hoongkunfun synthesisandxraycrystalstructureof1e14chlorophenylnhydroxy31himidazol1ylpropan1imine |
| _version_ |
1725699994635206656 |