Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage.

Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage.

HIV-1 cell entry commonly uses, in addition to CD4, one of the chemokine receptors CCR5 or CXCR4 as coreceptor. Knowledge of coreceptor usage is critical for monitoring disease progression as well as for supporting therapy with the novel drug class of coreceptor antagonists. Predictive methods for i...

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Bibliographic Details
Main Authors: Oliver Sander, Tobias Sing, Ingolf Sommer, Andrew J Low, Peter K Cheung, P Richard Harrigan, Thomas Lengauer, Francisco S Domingues
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1848001?pdf=render

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http://europepmc.org/articles/PMC1848001?pdf=render

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