Ameliorating Role of Caffeic Acid Phenethyl Ester (CAPE) Against Methotrexate-Induced Oxidative Stress in the Sciatic Nerve, Spinal Cord and Brain Stem Tissues of Rats

OBJECTIVE: Methotrexate (MTX)-associated neurotoxicity is an important clinical problem in cancer patients, but the mechanisms of MTX-induced neurotoxicity are not yet known exactly. The aims of this study were (1) to investigate the possible role of malondialdehyde (MDA), superoxide dismutase (SO...

Full description

Bibliographic Details
Main Authors: Ertuğrul Uzar, Hasan Rıfat Koyuncuoğlu, H. Ramazan Yılmaz, Efkan Uz, Ahmet Songar, Onder Sahin, Vedat Ali Yurekli, Mustafa Yılmaz, Serkan Kılbaş, Süleyman Kutluhan
Format: Article
Language:English
Published: Galenos Yayinevi 2010-03-01
Series:Türk Nöroloji Dergisi
Subjects:
Online Access:http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-75436