Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site

Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site

Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current antiandrogen therapies induce resistant mutations at the hormone binding pocket (HBP) that convert the activity of these agents from antagonist to agonist. Thus, there is a high unmet me...

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Bibliographic Details
Main Authors: Yangguang Liu, Meng Wu, Tianqi Wang, Yongli Xie, Xiangling Cui, Liujun He, Yang He, Xiaoyu Li, Mingliang Liu, Laixing Hu, Shan Cen, Jinming Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
androgen receptor
structural based drug design
antiandrogen
castration-resistant prostate cancer
activation function-2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01419/full

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