Synthesis and Characterization of a “Clickable” PBR28 TSPO-Selective Ligand Derivative Suitable for the Functionalization of Biodegradable Polymer Nanoparticles

Synthesis and Characterization of a “Clickable” PBR28 TSPO-Selective Ligand Derivative Suitable for the Functionalization of Biodegradable Polymer Nanoparticles

Reactive microgliosis is a pathological hallmark that accompanies neuronal demise in many neurodegenerative diseases, ranging from acute brain/spinal cord injuries to chronic diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and age-related dementia. One strategy to ass...

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Bibliographic Details
Main Authors: Renato Auriemma, Mattia Sponchioni, Umberto Capasso Palmiero, Giacomo Rossino, Arianna Rossetti, Andrea Marsala, Simona Collina, Alessandro Sacchetti, Davide Moscatelli, Marco Peviani
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Nanomaterials
Subjects:
neuroinflammation
microglia
TSPO
active targeting
click chemistry
polymer nanoparticles
Online Access:https://www.mdpi.com/2079-4991/11/7/1693

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