2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1H-1,3-oxazolo[3,4-a]pyridin-3-yl}phenol

2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1H-1,3-oxazolo[3,4-a]pyridin-3-yl}phenol

In the title mefloquine&#8211;oxazolidine derivative, C24H20F6N2O2, the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair conformation. The oxazoline and benzene residues lie away from the C6 ring of the quinoline group and, to a first ap...

Full description

Bibliographic Details
Main Authors:	Raoni S. B. Gon&#231;alves, Carlos R. Kaiser, Marcus V. N. de Souza, James L. Wardell, Solange M. S. V. Wardell, Edward R. T. Tiekink
Format:	Article
Language:	English
Published:	International Union of Crystallography 2011-07-01
Series:	Acta Crystallographica Section E
Online Access:	http://scripts.iucr.org/cgi-bin/paper?S1600536811022379

Similar Items

4-(3,3-Dimethylperhydro-1,3-oxazolo[3,4-a]pyridin-1-yl)-2,8-bis(trifluoromethyl)quinoline
by: Solange M. S. V. Wardell, et al.
Published: (2010-03-01)

Benzyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
by: Marcus V. N. de Souza, et al.
Published: (2011-12-01)

tert-Butyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
by: Raoni S. B. Gon&#231;alves, et al.
Published: (2011-12-01)

(R*,S*)-(&#177;)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate
by: Edward R. T. Tiekink, et al.
Published: (2011-10-01)

A kryptoracemic salt: 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium (+)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
by: James L. Wardell, et al.
Published: (2016-06-01)

2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 3-amino-5-nitrobenzoate sesquihydrate
by: Marcus V. N. de Souza, et al.
Published: (2011-11-01)

Bis(2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium) tetrachloridodiphenylstannate(IV)
by: Edward R. T. Tiekink, et al.
Published: (2010-03-01)

(E)-1-(2,5-Dichlorothiophen-3-yl)ethanone [8-(trifluoromethyl)quinolin-4-yl]hydrazone
by: Alexandra M. Z. Slawin, et al.
Published: (2012-03-01)

{5-Methyl-1-[8-(trifluoromethyl)quinolin-4-yl]-1H-1,2,3-triazol-4-yl}(morpholino)methanone
by: R. J. Butcher, et al.
Published: (2008-12-01)

3,4-Dimethoxybenzaldehyde [2,8-bis(trifluoromethyl)quinolin-4-yl]hydrazone
by: Waleed Fedl Ali Al-eryani, et al.
Published: (2010-07-01)

(E)-1-(4-Methylphenyl)ethanone [8-(trifluoromethyl)quinolin-4-yl]hydrazone
by: Grzegorz Dutkiewicz, et al.
Published: (2010-04-01)

2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium trichloroacetate: crystal structure and Hirshfeld surface analysis
by: James L. Wardell, et al.
Published: (2018-12-01)

Ethyl 4-{[1-(2,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}-8-(trifluoromethyl)quinoline-3-carboxylate
by: Hoong-Kun Fun, et al.
Published: (2012-10-01)

6-Methoxy-2-phenyl-4,4a,6,7,8,8a-hexahydro-2H-pyrano[3,2-d][1,3]dioxine-7,8-diyl bis(4-methylbenzene-1-sulfonate)
by: James L. Wardell, et al.
Published: (2012-03-01)

1,3-Diphenyl-8-trifluoromethyl-1H-pyrazolo[3,4-b]quinoline
by: Pawe&#322; Szlachcic, et al.
Published: (2012-07-01)

4-(4-Methylpiperazin-1-yl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)-7-(trifluoromethyl)quinoline
by: Hoong-Kun Fun, et al.
Published: (2011-11-01)

Ethyl 4-({1-[2-(4-bromophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methoxy)-8-(trifluoromethyl)quinoline-3-carboxylate
by: Arun M. Islor, et al.
Published: (2012-12-01)

3-(2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-yl)-1,5-bis(4-methoxyphenyl)biuret
by: Koichiro Nishibe, et al.
Published: (2010-03-01)

7-Chloro-4-[(E)-2-(3,4,5-trimethoxybenzylidene)hydrazin-1-yl]quinoline
by: Marcelle de Lima Ferreira, et al.
Published: (2012-04-01)

Crystal structure and Hirshfeld surface analysis of 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 2-hydroxy-2-phenylacetate hemihydrate
by: James L. Wardell, et al.
Published: (2016-11-01)

Nicotinaldehyde [2,8-bis(trifluoromethyl)quinolin-4-yl]hydrazone monohydrate
by: H. C. Devarajegowda, et al.
Published: (2010-09-01)

1-(4-Methylphenyl)-3-phenyl-1H-pyrazol-5-yl 4-nitrobenzenesulfonate
by: Solange M. S. V. Wardell, et al.
Published: (2012-04-01)

8-[(3-Phenyl-1,2,4-oxadiazol-5-yl)methoxy]quinoline monohydrate
by: Shu-Yuan Bai, et al.
Published: (2013-07-01)

8-(Naphthalen-1-yl)quinoline
by: Godwin Kanu, et al.
Published: (2011-09-01)

Methyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl]oxy}acetate
by: Zhi-Qiang Feng, et al.
Published: (2011-02-01)

4-(8-Ethoxy-2,3-dihydro-1H-cyclopenta[c]quinolin-4-yl)butane-1-peroxol
by: Jean Fotie, et al.
Published: (2010-07-01)

3-Chloro-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyridazine
by: Mehtap G&#246;k&#231;e, et al.
Published: (2010-03-01)

4-[5-(Furan-2-yl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide
by: Abdullah M. Asiri, et al.
Published: (2012-04-01)

tert-Butyl 3-(8-bromo-4H,10H-1,2-oxazolo[4,3-c][1]benzoxepin-10-yl)-2-methyl-1H-indole-1-carboxylate
by: Ankur Trigunait, et al.
Published: (2010-08-01)

(1R,2S,4S,4aS,8S,8aS)-4-Hydroxy-8,8a-dimethyl-10-oxo-2,3,4,7,8,8a-hexahydro-1H-4a,1-(epoxymethano)naphthalen-2-yl acetate
by: Ouassila Selaïmia-Ferdjani, et al.
Published: (2013-06-01)

3,3&#8242;-Bis(quinolin-8-yl)-1,1&#8242;-[4,4&#8242;-methylenebis(4,1-phenylene)]diurea
by: Avijit Pramanik, et al.
Published: (2012-01-01)

1-{1-[2,8-Bis(trifluoromethyl)-4-quinolyl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone
by: Bojapoojary, et al.
Published: (2010-10-01)

(2E)-3-(2-Chloro-8-methylquinolin-3-yl)-1-(2,4-dimethylquinolin-3-yl)prop-2-en-1-one
by: Edward R. T. Tiekink, et al.
Published: (2013-08-01)

[1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl]methanol hemihydrate
by: N&#252;bia Boechat, et al.
Published: (2011-11-01)

(8-Chloro-3-methyl-1H-pyrazolo[4,3-c]cinnolin-1-yl) (pyridin-4-yl)methanone
by: Ravinesh Mishra, et al.
Published: (2010-07-01)

(4S)-3-Methyl-5,6,7,8-tetrahydro-4H-spiro[[1,2]oxazolo[5,4-b]quinoline-4,3′-indole]-2′,5-dione
by: E. Govindan, et al.
Published: (2014-02-01)

4-(5-Phenyl-3-trifluoromethyl-1H-pyrazol-1-yl)benzenesulfonamide
by: Abdullah M. Asiri, et al.
Published: (2011-09-01)

2-[(3S,3aS,5R,8S,8aS)-3,8-Dimethylhexahydro-1H,4H-3a,8a-epoxyazulen-5-yl]propan-2-ol
by: Stacey Burrett, et al.
Published: (2014-07-01)

(2E)-3-(2-Chloro-8-methylquinolin-3-yl)-1-(2-methyl-4-phenylquinolin-3-yl)prop-2-en-1-one
by: Edward R. T. Tiekink, et al.
Published: (2013-08-01)

Methyl 1-{4-[(S)-2-(methoxycarbonyl)pyrrolidin-1-yl]-3,6-dioxocyclohexa-1,4-dien-1-yl}pyrrolidine-2-carboxylate
by: Simon J. Garden, et al.
Published: (2010-08-01)