2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1H-1,3-oxazolo[3,4-a]pyridin-3-yl}phenol

2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1H-1,3-oxazolo[3,4-a]pyridin-3-yl}phenol

In the title mefloquine–oxazolidine derivative, C24H20F6N2O2, the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair conformation. The oxazoline and benzene residues lie away from the C6 ring of the quinoline group and, to a first ap...

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Bibliographic Details
Main Authors: Raoni S. B. Gonçalves, Carlos R. Kaiser, Marcus V. N. de Souza, James L. Wardell, Solange M. S. V. Wardell, Edward R. T. Tiekink
Format: Article
Language:English
Published: International Union of Crystallography 2011-07-01
Series:Acta Crystallographica Section E
Online Access:http://scripts.iucr.org/cgi-bin/paper?S1600536811022379
Description
Summary:In the title mefloquine–oxazolidine derivative, C24H20F6N2O2, the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair conformation. The oxazoline and benzene residues lie away from the C6 ring of the quinoline group and, to a first approximation, to one side of the plane through the ten atoms (r.m.s. deviation = 0.025 Å). An intramolecular O—H...N(piperidine) hydrogen bond is present. The crystal packing features C—H...O, C—H...F and C—H...π(hydroxybenzene) interactions.
ISSN:1600-5368

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