Ongoing contact activation in patients with hereditary angioedema.

Ongoing contact activation in patients with hereditary angioedema.

Hereditary angioedema (HAE) is predominantly caused by a deficiency in C1 esterase inhibitor (C1INH) (HAE-C1INH). C1INH inhibits activated factor XII (FXIIa), activated factor XI (FXIa), and kallikrein. In HAE-C1INH patients the thrombotic risk is not increased even though activation of the contact...

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Bibliographic Details
Main Authors: Joke Konings, Massimo Cugno, Chiara Suffritti, Hugo Ten Cate, Marco Cicardi, José W P Govers-Riemslag
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3754953?pdf=render

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http://europepmc.org/articles/PMC3754953?pdf=render

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