Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

Laboratory mice develop populations of circulating memory CD4+ T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). However, the nature, relative importance and timing of...

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Bibliographic Details
Main Authors: Thea Hogan, Maria Nowicka, Daniel Cownden, Claire F Pearson, Andrew J Yates, Benedict Seddon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/48901