Revisiting Cu(II) Bound Amyloid-β40 and Amyloid-β42 Peptides: Varying Coordination Chemistries

Revisiting Cu(II) Bound Amyloid-β40 and Amyloid-β42 Peptides: Varying Coordination Chemistries

Metal ions and intrinsically disordered peptides amyloid-β40 and amyloid-β42 are at the center of Alzheimer´s disease pathology. Divalent copper ion binds to amyloid-β40 and amyloid-β42 peptides with varying coordination chemistries. Experiments face challenges in the measurements of divalent copper...

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Bibliographic Details
Main Author: Orkid Coşkuner-Weber
Format: Article
Language:English
Published: Turkish Chemical Society 2018-08-01
Series:Journal of the Turkish Chemical Society, Section A: Chemistry
Subjects:
Copper
amyloid-β
coordination chemistry
replica exchange molecular dynamics simulations
Alzheimer's disease
Online Access:http://dergipark.gov.tr/jotcsa/issue/37193/424144

Internet

http://dergipark.gov.tr/jotcsa/issue/37193/424144

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